Anticorps Polyclonal de lapin anti-Nesprin1/Syne-1

Nesprin1/Syne-1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31095-1-PBS

Synonymes

SYNE1, MYNE1, Myne 1, Enaptin, CPG2

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Galerie de données de validation

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  WB analysis using 31095-1-AP (same clone as 31095-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31095-1-AP (SYNE1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31095-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31095-1-PBS cible Nesprin1/Syne-1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Nesprin1/Syne-1 Protéine recombinante Ag34809
• Nom complet: spectrin repeat containing, nuclear envelope 1
• Poids moléculaire observé: 120 kDa, 367 kDa, 642 kDa, 1000 kDa
• Numéro d’acquisition GenBank: BC039121
• Symbole du gène: SYNE1
• Identification du gène (NCBI): 23345
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SYNE1, also known as spectrin repeat containing nuclear envelope protein 1. It is expressed in skeletal and smooth muscle, as well as peripheral blood lymphocytes, and localizes to the nuclear membrane. Mutations in the SYNE1 gene have been associated with several diseases, including autosomal recessive spinocerebellar ataxia type 8 (also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce) and Emery-Dreifuss muscular dystrophy 4, autosomal dominant. The SYNE1 gene exhibits ubiquitous expression across various tissues, including the ovary and bone marrow. The molecular weight of the SYNE1 protein can vary depending on the specific isoform. For example, the full-length nesprin-1 isoform, also known as nesprin-1 giant, has 8797 amino acids and a molecular weight of approximately 1000 kDa. Another isoform, nesprin-1α2, has a molecular weight of about 120 kDa (PMID: 27782104). The protein has other isoforms with molecular weights of 380 kDa, 167 kDa and 642 kDa respectively.

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