Anticorps Recombinant de lapin anti-Neuroserpin

Neuroserpin Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250112E7

N° de cat : 85923-1-PBS

Synonymes

Serpin I1, Peptidase inhibitor 12, PI 12, PI12, PI-12

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Galerie de données de validation

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  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (SERPINI1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (Neuroserpin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (SERPINI1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 85923-1-RR (same clone as 85923-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 85923-1-RR (Neuroserpin antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85923-1-PBS cible Neuroserpin dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, souris

• Réactivité: Humain, porc, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Neuroserpin Protéine recombinante Eg2819
• Nom complet: serpin peptidase inhibitor, clade I (neuroserpin), member 1
• Masse moléculaire calculée: 46 kDa
• Poids moléculaire observé: 46 kDa
• Numéro d’acquisition GenBank: NM_005025.4
• Symbole du gène: Neuroserpin
• Identification du gène (NCBI): 5274
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.

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