Anticorps Monoclonal anti-NeutraKine® IL-10

NeutraKine® IL-10 Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain et plus (1)

Applications

ELISA, Cell treatment

Conjugaison

Non conjugué

Publications(1)

CloneNo.

7B8G3

N° de cat : 69018-2-Ig

Synonymes

CSIF, IL 10, IL10, IL10A, interleukin 10, TGIF

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Galerie de données de validation

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Informations sur le produit

69018-2-Ig cible NeutraKine® IL-10 dans les applications de ELISA, Cell treatment et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: souris
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: human Humankine IL-10 protein HZ-1145
• Nom complet: interleukin 10
• Symbole du gène: IL-10
• Identification du gène (NCBI): 3586
• Conjugaison: Non conjugué
• Forme: Lyophilized Powder
• Méthode de purification: Purification par protéine A
• Tampon de stockage: Sterile PBS
• Endotoxin: <0.1 EU/μg
• Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
• Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Informations générales

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, and autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

This antibody can be used to neutralize the bioactivity of IL-10.

Publications

Species	Application	Title
mouse	Cell treatment	Environ Pollut; Aluminum promotes B1 cells to produce IL-10 and impairs adaptive immune system; Authors - Ting Liu

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