Anticorps Monoclonal anti-NeutraKine® IL-10
NeutraKine® IL-10 Monoclonal Antibody for ELISA
Hôte / Isotype
Mouse / IgG2b
Réactivité testée
Humain
Applications
, ELISA
Conjugaison
Non conjugué
CloneNo.
7B8G3
N° de cat : 69018-2-Ig
Synonymes
Galerie de données de validation
Informations sur le produit
69018-2-Ig cible NeutraKine® IL-10 dans les applications de , ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Mouse / IgG2b |
| Clonalité | Monoclonal |
| Type | Anticorps |
| Immunogène | human Humankine IL-10 protein HZ-1145 |
| Nom complet | interleukin 10 |
| Symbole du gène | IL10 |
| Identification du gène (NCBI) | 3586 |
| Conjugaison | Non conjugué |
| Forme | Lyophilized Powder |
| Méthode de purification | Purification par protéine A |
| Tampon de stockage | PBS stérile. |
| Endotoxin | <0.1 EU/μg |
| Reconstitution | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Informations générales
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, and autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
This antibody can be used to neutralize the bioactivity of IL-10.
