Anticorps Monoclonal anti-NeutraKine®IL-12 p35

NeutraKine®IL-12 p35 Monoclonal Antibody for Neutralization, ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

Neutralization, ELISA

Conjugaison

Non conjugué

CloneNo.

2G11G6

N° de cat : 69029-1-Ig

Synonymes

CLMF, CLMF p35, IL 12 subunit p35, IL 12A, IL-12 p35, IL12A, Interleukin 12 subunit alpha, NFSK, NKSF1, P35



Neutralization

Informations sur le produit

69029-1-Ig cible NeutraKine®IL-12 p35 dans les applications de Neutralization, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG2b
Clonalité Monoclonal
Type Anticorps
Immunogène human HumankineIL-12 p35 protein HZ-1256
Nom complet interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Symbole du gène IL12A
Identification du gène (NCBI) 3592
Conjugaison Non conjugué
Forme Lyophilized Powder
Méthode de purification Purification par protéine A
Tampon de stockage PBS stérile.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Informations générales

IL-12 p35 is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

This antibody can be used to neutralize the bioactivity of IL-12 p35.