Anticorps Monoclonal anti-NeutraKine® IL-6

NeutraKine® IL-6 Monoclonal Antibody for IHC, Neutralization, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

IHC, Neutralization, ELISA

Conjugaison

Non conjugué

CloneNo.

4G3E6

N° de cat : 69001-1-PBS

Synonymes

IL6, IL-6, 4G3E6, B-cell stimulatory factor 2, IFN-beta-2



Informations sur le produit

69001-1-PBS cible NeutraKine® IL-6 dans les applications de IHC, Neutralization, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG1
Clonalité Monoclonal
Type Anticorps
Immunogène human Humankine IL-6 protein HZ-1019
Nom complet interleukin 6 (interferon, beta 2)
Symbole du gène IL6
Identification du gène (NCBI) 3569
Conjugaison Non conjugué
Forme Lyophilized Powder
Méthode de purification Purification par protéine G
Tampon de stockage PBS only
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Informations générales

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

This antibody can be used to neutralize the bioactivity of IL-6.

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