Anticorps Monoclonal anti-NeutraKine®IL-9

NeutraKine®IL-9 Monoclonal Antibody for Neutralization, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

Neutralization, ELISA

Conjugaison

Non conjugué

CloneNo.

1B3A10

N° de cat : 69031-1-Ig

Synonymes

Cytokine P40, HP40, IL 9, IL9, IL-9, interleukin 9, P40, T cell growth factor P40

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Galerie de données de validation

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  Neutralization experiment of NeutraKine®IL-9 using 69031-1-Ig

  Recombinant human IL-9 (Cat.NO. HZ-1240) stimulates proliferation of the MO7e human megakaryoblastic leukemia cell line in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human IL-9 (0.8 ng/mL HZ-1240) is neutralized by mouse anti-human IL-9 monoclonal antibody 69031-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 0.2-1.0 μg/mL. Mouse IgG1 Isotype Control monoclonal antibody 66360-1-Ig was served as control (green curve, refer to top X-right Y axis).

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Neutralization

Informations sur le produit

69031-1-Ig cible NeutraKine®IL-9 dans les applications de Neutralization, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: human HumankineIL-9 protein HZ-1240
• Nom complet: interleukin 9
• Symbole du gène: IL9
• Identification du gène (NCBI): 3578
• Conjugaison: Non conjugué
• Forme: Lyophilized Powder
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS stérile.
• Endotoxin: <0.1 EU/μg
• Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
• Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Informations générales

Interleukin 9 (IL-9) is a γc-family cytokine that is highly produced by T-helper 9 (Th9) cells. IL-9 could promote the survival and activation of various cellular targets, including mast cells, B cells, T cells, and structural cells. Its expression is considered a hallmark of Th2-lineage cells. Primarily studied in Th2-type immunity, IL-9 was shown to be involved in asthma, allergy, and host defense against helminth infections. IL-9 also stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes.

This antibody can be used to neutralize the bioactivity of IL-9.