Anticorps Polyclonal de lapin anti-OFD1

OFD1 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22851-1-PBS

Synonymes

71 7A, Centriole and centriolar satellite protein OFD1, CXorf5, Oral-facial-digital syndrome 1 protein, Protein 71 7A

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Galerie de données de validation

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  IHC staining of human brain using 22851-1-AP (same clone as 22851-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22851-1-AP (OFD1 Antibody) at dilution of 1:50. (under 10x lens). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IHC staining of human brain using 22851-1-AP (same clone as 22851-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 22851-1-AP (OFD1 Antibody) at dilution of 1:50. (under 40x lens). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IF Staining of HEK-293 using 22851-1-AP (same clone as 22851-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using OFD1 antibody (22851-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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  IF Staining of hTERT-RPE1 using 22851-1-AP (same clone as 22851-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed hTERT-RPE1 cells using OFD1 antibody (22851-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2), CoraLite®594 ARL13B antibody (CL594-17711, red). This data was developed using the same antibody clone with 22851-1-PBS in a different storage buffer formulation.

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Informations sur le produit

22851-1-PBS cible OFD1 dans les applications de IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: OFD1 Protéine recombinante Ag18898
• Nom complet: oral-facial-digital syndrome 1
• Masse moléculaire calculée: 1012 aa, 117 kDa
• Poids moléculaire observé: 110-120 kDa
• Numéro d’acquisition GenBank: BC096344
• Symbole du gène: OFD1
• Identification du gène (NCBI): 8481
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

OFD1, also named CXorf5 and 71-7A, belongs to the OFD1 family. It has been implicated in several developmental syndromes, including a male-lethal X-linked dominant condition, Oral-Facial-Digital type 1 (OFD1) syndrome, X-linked recessiveSimpson-Golabi-Behmel syndrome type 2 (SGBS2), and Joubert syndrome and related disorders (JSRDs). It is a component of the centrioles controlling mother and daughter centrioles' length. It recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. OFD1 plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. This antibody recognizes all the isoforms of OFD1. The 43 kDa is isoform 2. The ~80 kDa band is unknown.

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