Anticorps Recombinant de lapin anti-OIP5

OIP5 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250073A7

N° de cat : 85757-5-PBS

Synonymes

CT86, LINT 25, LINT25, MIS18B, OIP 5

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Galerie de données de validation

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  WB analysis using 85757-5-RR (same clone as 85757-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85757-5-RR (OIP5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85757-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85757-5-RR

  Biolayer interferometry (BLl) kinetic assays of 85757-5-RR against Human OIP5 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

85757-5-PBS cible OIP5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: OIP5 Protéine recombinante Ag2790
• Nom complet: Opa interacting protein 5
• Masse moléculaire calculée: 229 aa, 25 kDa
• Poids moléculaire observé: 25-30 kDa
• Numéro d’acquisition GenBank: BC015050
• Symbole du gène: OIP5
• Identification du gène (NCBI): 11339
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

OIP5 is also known as Mis18β. Vertebrates possess two Mis18 paralogs, Mis18α and Mis18β. Mis18 has been previously shown to affect histone modifications and the methylation status of underlying chromatin . Eliminating histone methylation within the alpha satellite DNA repeats of a human artificial chromosome alters the recruitment of HJURP .The Mis18core complex was originally characterized as an oligomer with a proposed 2:2 stoichiometry of Mis18α and Mis18β, but additional work demonstrated a 4:2 Mis18α:Mis18β hexamer. (PMID: 31492860, PMID: 26942680)

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