Anticorps Monoclonal anti-OLIG2

OLIG2 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

1E8C5

N° de cat : 66513-1-PBS

Synonymes

OLIG2 (for WB only), 1E8C5, 5O7, bHLHb1, bHLHe19

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Galerie de données de validation

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  WB analysis of human brain using 66513-1-Ig (same clone as 66513-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 66513-1-Ig (OLIG2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66513-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human cerebellum using 66513-1-Ig (same clone as 66513-1-PBS)

  human cerebellum tissue were subjected to SDS PAGE followed by western blot with 66513-1-Ig (OLIG2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66513-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66513-1-PBS cible OLIG2 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: OLIG2 Protéine recombinante Ag18838
• Nom complet: oligodendrocyte lineage transcription factor 2
• Masse moléculaire calculée: 32 kDa
• Poids moléculaire observé: 35-39 kDa
• Numéro d’acquisition GenBank: BC047511
• Symbole du gène: OLIG2
• Identification du gène (NCBI): 10215
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

OLIG2, also named as BHLHB1, BHLHE19, PRKCBP2 and RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1, OLIG2 establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. OLIG2 is widely expressed in subsets of glia cells and progenitors, and it is strongly induced at different sites by both acute and chronic injury, albeit with different mechanisms. OLIG2 acts as a repressor of neurogenesis in cells reacting to brain injury. It may represent an effective approach towards evoking neuronal repair from parenchymal precursors.(PMID:19390819 )

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