Anticorps Recombinant de lapin anti-OLR1/LOX1

OLR1/LOX1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250525B12

N° de cat : 98524-3-PBS

Synonymes

OLR1, CLEC8A, C-type lectin domain family 8 member A, hLOX 1, hLOX1

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Galerie de données de validation

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  FC experiment of human PBMCs using 98524-3-RR (same clone as 98524-3-PBS)

  1x10^6 untreated or GM-CSF-treated human PBMCs were surface stained with 0.25 ug Anti-Human OLR1/LOX1 Rabbit RecAb (98524-3-RR, Clone: 250525B12) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD14. Cells were not fixed. Monocytes were gated. This data was developed using the same antibody clone with 98524-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98524-3-RR (same clone as 98524-3-PBS)

  1x10^6 GM-CSF-treated human PBMCs were surface stained with 0.25 ug Anti-Human OLR1/LOX1 Rabbit RecAb (98524-3-RR, Clone: 250525B12) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human OLR1/LOX1 Rabbit RecAb (98524-3-RR, Clone: 250525B12) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Monocytes were gated. This data was developed using the same antibody clone with 98524-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98524-3-PBS cible OLR1/LOX1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: OLR1/LOX1 Protéine recombinante Eg2911
• Nom complet: oxidized low density lipoprotein (lectin-like) receptor 1
• Masse moléculaire calculée: 31 kDa
• Numéro d’acquisition GenBank: NM_002543.3
• Symbole du gène: OLR1
• Identification du gène (NCBI): 4973
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

OLR1/LOX-1 acts as a receptor, in the form of homodimer, that mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein (oxLDL) (PMID: 9052782, 15695803). ORL1 is predominantly expressed in endothelial cells and vascular-rich organs such as the placenta, lung, liver, and brain (PMID: 9828121). OLR1 is a protein containing 273 amino acids with a calculated molecular mass of 31 kDa but an apparent molecular mass of 50 kDa, which may result from the glycosylation of four potential N-linked glycosylation sites located at the C-terminal domain (PMID: 9052782).

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