Anticorps Polyclonal de lapin anti-OSTbeta / SLC51B

OSTbeta / SLC51B Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 21248-1-PBS

Synonymes

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Galerie de données de validation

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  IHC staining of human small intestine using 21248-1-AP (same clone as 21248-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 21248-1-PBS in a different storage buffer formulation.

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  IHC staining of human small intestine using 21248-1-AP (same clone as 21248-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 21248-1-PBS in a different storage buffer formulation.

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Informations sur le produit

21248-1-PBS cible OSTbeta / SLC51B dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: OSTbeta / SLC51B Protéine recombinante Ag15751
• Nom complet: organic solute transporter beta
• Masse moléculaire calculée: 128 aa, 14 kDa
• Numéro d’acquisition GenBank: BC103842
• Symbole du gène: SLC51B
• Identification du gène (NCBI): 123264
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Organic solute transporter alpha-beta (Ostα-Ostβ) is a heteromeric transporter that has been localized to the basolateral membrane of epithelial cells of the small intestine, kidney and liver, and appears to be essential for bile acid homeostasis. The transporter is composed of a predicted 340-amino acid, 7-transmembrane domain protein (Ostα) and a putative 128-amino acid, single-transmembrane domain polypeptide (Ostβ). Ostα-Ostβ transports bile acids by a facilitated diffusion mechanism; therefore, Ostα-Ostβ can mediate cellular efflux or uptake depending on the substrate's electrochemical gradient. It's reported that Ostα-Ostβ is not only essential for bile acid, but also vital for sterol disposition and enterohepatic circulation(PMID: 21691099).

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