Anticorps Polyclonal de lapin anti-P2RY11

P2RY11 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20191-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 20191-1-AP (same clone as 20191-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20191-1-AP (P2RY11 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20191-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20191-1-PBS cible P2RY11 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: P2RY11 Protéine recombinante Ag14106
• Nom complet: purinergic receptor P2Y, G-protein coupled, 11
• Masse moléculaire calculée: 374 aa, 40 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC009877
• Symbole du gène: P2RY11
• Identification du gène (NCBI): 5032
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Nucleotides, the structural subunits of the nucleic acids, are also important extracellular signaling molecules. P2 receptors are a family of cell surface receptors that mediate a wide variety of physiologic effects in response to extracellular nucleotides. These receptors fall into two classes: P2X receptors, which are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP, and P2Y receptors, which are G protein-coupled receptors (GPCRs). P2Y purinoceptor 11 (P2RY11) is a receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. It is not activated by UTP or UDP (PMID: 9405388). Expression of P2RY11 has been detected in immune cells including dendritic cells, macrophages and non‐immune cells including cancer cells (PMID: 33463722). It is involved in immune regulation (PMID: 27246167). No murine P2ry11 has been identified.

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