Anticorps Polyclonal de lapin anti-PAK3

PAK3 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32848-1-PBS

Synonymes

Beta-PAK, EC:2.7.11.1, Oligophrenin-3, OPHN3, p21-activated kinase 3

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Galerie de données de validation

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  WB analysis using 32848-1-AP (same clone as 32848-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32848-1-AP (PAK3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32848-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32848-1-PBS cible PAK3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PAK3 Protéine recombinante Ag38566
• Nom complet: p21 protein (Cdc42/Rac)-activated kinase 3
• Masse moléculaire calculée: 62kDa，559aa
• Poids moléculaire observé: 64 kDa
• Numéro d’acquisition GenBank: NM_001128173.2
• Symbole du gène: PAK3
• Identification du gène (NCBI): 5063
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PAK3, also known as p21-activated kinase 3, is a member of the PAK family of serine/threonine protein kinases, classified as Group I PAK kinases along with PAK1 and PAK2. PAK3 is predominantly expressed in neural cells, especially in regions such as the brain. PAK3 plays a crucial role in dendritic spine development and synaptic plasticity. PAK3 plays an important role in cell migration and morphology. It regulates dynamic changes in the actomyosin cytoskeleton, microtubules, and adhesion interactions with the microenvironment. In neurons and other cell types, PAK3 contributes to cell migration, neurite growth, and dendritic spine morphogenesis by participating in signaling cascades that control cell adhesion and cell motility. Mutations in PAK3 are associated with X-linked non-syndromic intellectual disability.

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