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Anticorps Polyclonal de lapin anti-PALB2

PALB2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14340-1-PBS

Synonymes

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using PALB2 Polyclonal antibody (14340-1-AP)

    WB analysis using 14340-1-AP (same clone as 14340-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14340-1-AP (PALB2 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14340-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using PALB2 Polyclonal antibody (14340-1-AP)

    IHC staining of human breast cancer using 14340-1-AP (same clone as 14340-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 14340-1-AP (PALB2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14340-1-PBS in a different storage buffer formulation.

Informations sur le produit

14340-1-PBS cible PALB2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène PALB2 Protéine recombinante Ag5654
Nom complet partner and localizer of BRCA2
Masse moléculaire calculée 131 kDa
Poids moléculaire observé 130 kDa; 80-90 kDa; 250-260 kDa
Numéro d’acquisition GenBankBC044254
Symbole du gène PALB2
Identification du gène (NCBI) 79728
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PALB2 can interact with BRCA1 and BRCA2 and form the BRCA1-PALB2-BRCA2 complex which is critical for homologous recombination and DNA damage response. PALB2 is an essential partner of BRCA2 that promotes the localization and stability of BRCA2. The predicted MW of PALB2 is approximately 130 kDa, while the truncated PALB2 protein arround 80-90 kDa can also be detected in SDS-PAGE similar to papers. (PubMed:16793542, 24141787, 24153426). There's the dimer form with MW 250-260 kDa (refer to PMID: 30289697).

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