Anticorps Recombinant de lapin anti-PARP10

PARP10 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Conjugaison

Non conjugué

CloneNo.

250454D4

N° de cat : 86096-1-PBS

Synonymes

ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, EC:2.4.2.-, PARP 10, PARP-10

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Galerie de données de validation

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  WB analysis using 86096-1-RR (same clone as 86096-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86096-1-RR (PARP10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86096-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86096-1-PBS cible PARP10 dans les applications de et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PARP10 Protéine recombinante Ag23457
• Nom complet: poly (ADP-ribose) polymerase family, member 10
• Poids moléculaire observé: 150 kDa
• Numéro d’acquisition GenBank: BC136542
• Symbole du gène: PARP10
• Identification du gène (NCBI): 84875
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PARP10 (Poly(ADP-ribose) polymerase family member 10) is a mono-ADP-ribosyltransferase that belongs to the PARP family. It regulates a variety of cellular functions, including gene transcription, DNA repair, and cell cycle control, by catalyzing ADP-ribosylation reactions. PARP10 is distributed in both the nucleus and cytoplasm, participating in the cellular response to DNA damage. In particular, its expression level significantly increases in response to UV-induced DNA damage. Additionally, PARP10 plays a crucial role in the antiviral response, being highly upregulated by interferon (IFN) to inhibit the replication of certain viruses and block protein translation during viral replication. PARP10 is also involved in immune regulation, interacting with NEMO to block the NF-κB signaling pathway and the production of pro-inflammatory cytokines.

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