Anticorps Polyclonal de lapin anti-PAX8

PAX8 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

IF

Conjugaison

Non conjugué

Publications

2

N° de cat : 21384-1-AP

Synonymes

paired box 8, Paired box protein Pax 8, PAX 8, PAX8

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Galerie de données de validation

• 

  WB analysis of mouse brain using 21384-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 21384-1-AP (PAX8 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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Applications testées

Dilution recommandée

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below

Informations sur le produit

21384-1-AP cible PAX8 dans les applications de IF et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PAX8 Protéine recombinante Ag16019
• Nom complet: paired box 8
• Masse moléculaire calculée: 450 aa, 48 kDa
• Numéro d’acquisition GenBank: BC001060
• Symbole du gène: PAX8
• Identification du gène (NCBI): 7849
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. PAX8 can be used in a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. Mutation of PAX8 will cause congenital hypothyroidism non-goitrous type 2 (CHNG2). This antibody is specific to Pax8.

Publications

Species	Application	Title
human	IF	Sci Rep; Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.; Authors - Nur Yucer
mouse		Cell Rep; Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.; Authors - Nur Yucer