Anticorps Monoclonal anti-PAX8

PAX8 Monoclonal Antibody for Cytometric bead array, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1C5A11

N° de cat : 60144-1-PBS

Synonymes

PAX-8, PAX 8, Paired box protein Pax-8, Paired box protein Pax 8, paired box 8

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Galerie de données de validation

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  Cytometric bead array standard curve of MP50408-4

  Cytometric bead array standard curve of MP50408-4, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-2-PBS. Standard:Ag0306. Range: 0.781-100 ng/mL.

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  Cytometric bead array standard curve of MP50408-5

  Cytometric bead array standard curve of MP50408-5, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-1-PBS. Standard:Ag0306. Range: 1.563-100 ng/mL.

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Informations sur le produit

60144-1-PBS cible PAX8 dans les applications de Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: PAX8 Protéine recombinante Ag0306
• Nom complet: paired box 8
• Masse moléculaire calculée: 48 kDa
• Numéro d’acquisition GenBank: BC001060
• Symbole du gène: PAX8
• Identification du gène (NCBI): 7849
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.

PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356).

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