Anticorps Recombinant de lapin anti-PD-ECGF

PD-ECGF Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251581B2

N° de cat : 86618-3-PBS

Synonymes

TYMP, EC:2.4.2.4, ECGF1, Gliostatin, Platelet-derived endothelial cell growth factor

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Galerie de données de validation

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  WB analysis using 86618-3-RR (same clone as 86618-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86618-3-RR (PD-ECGF antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86618-3-PBS in a different storage buffer formulation.

• 

  WB analysis using 86618-3-RR (same clone as 86618-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86618-3-RR (PD-ECGF antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86618-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86618-3-RR

  Biolayer interferometry (BLl) kinetic assays of 86618-3-RR against Human PD-ECGF were performed. The affinity constant is 1.64 nM.

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Informations sur le produit

86618-3-PBS cible PD-ECGF dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PD-ECGF Protéine recombinante Ag3052
• Nom complet: thymidine phosphorylase
• Masse moléculaire calculée: 482 aa, 50 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC018160
• Symbole du gène: Thymidine phosphorylase
• Identification du gène (NCBI): 1890
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Platelet derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP), induces migration and angiogenesis in endothelial and tumor cells, and was upregulated in various malignancies compared to that in normal tissues. Interestingly, PD-ECGF has dual effect on tumor development and chemotherapy. It could stimulate cancer cell migration and proliferation. On the other hand, some chemotherapeutic agents (5-fluorouracil, capecitabine, etc.) were converted to their active forms through TP enzymes.

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