Anticorps Polyclonal de lapin anti-PDE4B

PDE4B Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31730-1-PBS

Synonymes

DPDE4, PDE32, PDE4B5, PDEIVB

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Galerie de données de validation

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  WB analysis using 31730-1-AP (same clone as 31730-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31730-1-AP (PDE4B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 31730-1-AP (same clone as 31730-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 31730-1-AP (PDE4B antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat brain using 31730-1-AP (same clone as 31730-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 31730-1-AP (PDE4B antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat brain using 31730-1-AP (same clone as 31730-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 31730-1-AP (PDE4B antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 31730-1-AP (same clone as 31730-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 31730-1-AP (PDE4B antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31730-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31730-1-PBS cible PDE4B dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PDE4B Protéine recombinante Ag35552
• Nom complet: phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
• Masse moléculaire calculée: 736 aa, 83 kDa
• Poids moléculaire observé: 83 kDa
• Numéro d’acquisition GenBank: BC105040
• Symbole du gène: PDE4B
• Identification du gène (NCBI): 5142
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PDE4B, also known as DPDE4, is a member of the PDE family of type IV cAMP-specific cyclic nucleotides. PDE4B regulates the cellular concentration of cyclic nucleotides and thus plays a role in signal transduction of inflammatory factors. Among all subtypes of PDE4, PDE4B is closely associated with cancer and has a major contribution to the role in hematological malignancies. PDE4B is distributed in multiple tissues, especially myeloid cells (PMID: 35899614, PMID: 36278172).

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