Anticorps Recombinant de lapin anti-PDGFR beta/CD140b

PDGFR beta/CD140b Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241754F6

N° de cat : 98207-1-RR

Synonymes

241754F6, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b

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Galerie de données de validation

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  FC experiment of NIH/3T3 using 98207-1-RR

  1x10^6 NIH/3T3 cells (left) or mouse splenocytes (right) were surface stained with 0.25 ug Anti-Mouse PDGFR beta/CD140b Rabbit Recombinant Antibody (98207-1-RR, Clone: 241754F6) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98207-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98207-1-RR against Mouse PDGFR beta/CD140b were performed. The affinity constant is below 1 pM.

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Applications testées

• Résultats positifs en cytométrie: cellules NIH/3T3,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98207-1-RR cible PDGFR beta/CD140b dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PDGFR beta/CD140b Protéine recombinante Eg1533
• Nom complet: platelet derived growth factor receptor, beta polypeptide
• Masse moléculaire calculée: 123kDa
• Numéro d’acquisition GenBank: NM_008809.2
• Symbole du gène: PDGFR beta
• Identification du gène (NCBI): 18596
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

The Platelet-Derived Growth Factor Receptor Beta (PDGFR beta, also known as CD140b) is a receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, migration, and survival. In mice, PDGFR beta is particularly significant due to its expression in pericytes, which are cells that reside on the walls of capillaries and play a vital role in maintaining vascular stability and integrity (PMID: 20738866). In the central nervous system (CNS) of mice, PDGFR beta is predominantly expressed in pericytes and vascular smooth muscle cells. It is involved in the formation and maintenance of the blood-brain barrier, as well as in the regulation of angiogenesis and vascular stability. Research in mouse models has shown that PDGFR beta signaling is crucial for tissue repair and functional recovery after stroke. Mice with disrupted PDGFR beta signaling exhibit delayed recovery and increased infarction volume following cerebral ischemia (PMID: 21952111).

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