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Anticorps Monoclonal anti-PMS2

PMS2 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1G4E6

N° de cat : 66075-1-PBS

Synonymes

1G4E6, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL

Galerie de données de validation

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  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    Vairous cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using PMS2 Monoclonal antibody (66075-1-Ig)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

Informations sur le produit

66075-1-PBS cible PMS2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Mouse / IgG2a
Clonalité Monoclonal
Type Anticorps
Immunogène PMS2 Protéine recombinante Ag12661
Nom complet PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Masse moléculaire calculée 862 aa, 96 kDa
Poids moléculaire observé 100 kDa
Numéro d’acquisition GenBankBC093921
Symbole du gène PMS2
Identification du gène (NCBI) 5395
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).

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