Anticorps Recombinant de lapin anti-PON2

PON2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251083G7

N° de cat : 86347-3-PBS

Synonymes

A-esterase 2, Aromatic esterase 2, EC:3.1.1.2, paraoxonase 2, Serum aryldialkylphosphatase 2

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Galerie de données de validation

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  WB analysis using 86347-3-RR (same clone as 86347-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86347-3-RR (PON2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86347-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86347-3-RR

  Biolayer interferometry (BLl) kinetic assays of 86347-3-RR against Human PON2 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

86347-3-PBS cible PON2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PON2 Protéine recombinante Ag5759
• Nom complet: paraoxonase 2
• Masse moléculaire calculée: 39 kDa
• Poids moléculaire observé: 37~39 kDa
• Numéro d’acquisition GenBank: BC046160
• Symbole du gène: PON2
• Identification du gène (NCBI): 5445
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PON2(Serum paraoxonase/arylesterase 2) has antioxidant activity and can prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Highest levels of PON2 protein are found in the mouse lung and small intestine, followed by the heart and liver, while lower levels are present in the testis, kidney and brain. PON2 expression in tissues from female mice is always significantly higher than in male animals. There are also some reports showing two bands of 43 kDa and 53 kDa to be detected through western blot as the two isoforms of this protein. (PMID:21354197).

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