Anticorps Recombinant de lapin anti-PON3

PON3 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242035D11

N° de cat : 84604-4-PBS

Synonymes

Paraoxonase 3 , Paraoxanase-3, EC:3.1.8.1, 242035D11

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Galerie de données de validation

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  WB analysis using 84604-4-RR (same clone as 84604-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84604-4-RR (PON3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84604-4-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 84604-4-RR (same clone as 84604-4-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 84604-4-RR (PON3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84604-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84604-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84604-4-RR against Human PON3 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84604-4-PBS cible PON3 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PON3 Protéine recombinante Ag36602
• Nom complet: paraoxonase 3
• Masse moléculaire calculée: NM_000940.2 40kDa，354aa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: NM_000940.2
• Symbole du gène: PON3
• Identification du gène (NCBI): 5446
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PON3, a member of the paraoxonase family, is expressed primarily in the liver and encodes a protein that is secreted into the bloodstream and binds to high-density lipoprotein (HDL). It also rapidly hydrolyzes lactones and inhibits the oxidation of low-density lipoprotein (LDL), thereby slowing the onset and progression of atherosclerosis. In addition, PON3 is closely associated with hepatocellular carcinoma (HCC), and is a potential therapeutic target for HCC by inducing cell cycle arrest and further inhibiting HCC cell proliferation.

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