Anticorps Polyclonal de lapin anti-PPP3CA-specific

PPP3CA-specific Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55147-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse brain using 55147-1-AP (same clone as 55147-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 55147-1-AP (PPP3CA-specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55147-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse pancreas using 55147-1-AP (same clone as 55147-1-PBS)

  mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 55147-1-AP (PPP3CA-specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55147-1-PBS in a different storage buffer formulation.

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Informations sur le produit

55147-1-PBS cible PPP3CA-specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
• Masse moléculaire calculée: 59 kDa
• Poids moléculaire observé: 59 kDa
• Numéro d’acquisition GenBank: NM_000944
• Symbole du gène: PPP3CA
• Identification du gène (NCBI): 5530
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PPP3CA, also called calcineurin Aα, is the only serine/threonine protein phosphatase under the control of Ca2+/calmodulin, and plays a critical role in the coupling of Ca2+ signals to cellular responses. Ca2+ signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. Therefore, PPP3CA plays an important role in muscle differentiation, especially in muscle fiber type conversion. It is also involved in osteoclast regulation, regulating bone formation through an effect on osteoblast differentiation. This antibody is specific to PPP3CA.

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