Anticorps Recombinant de lapin anti-PRDX1

PRDX1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251425E8

N° de cat : 86589-1-PBS

Synonymes

EC:1.11.1.24, MSP23, Natural killer cell-enhancing factor A, NKEF-A, PAG

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Galerie de données de validation

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  WB analysis using 86589-1-RR (same clone as 86589-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 86589-1-RR (PRDX1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86589-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86589-1-PBS cible PRDX1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: PRDX1 Protéine recombinante Ag8602
• Nom complet: peroxiredoxin 1
• Masse moléculaire calculée: 199 aa, 22 kDa
• Poids moléculaire observé: 23 kDa
• Numéro d’acquisition GenBank: BC007063
• Symbole du gène: PRDX1
• Identification du gène (NCBI): 5052
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PRDX1 (Peroxiredoxin-1), also named as PAGA, PAGB, TDPX2, PAG or NKEF-A, belongs to the ahpC/TSA family. PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 (PMID: 9497357). It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. PRDX1 can form a dimer, and also can be phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity (PMID: 22583657, 11986303).

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