Anticorps Monoclonal anti-PRMT5

PRMT5 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

4A1B5

N° de cat : 68534-1-PBS

Synonymes

72 kDa ICln binding protein, HRMT1L5, IBP72, Jak binding protein 1, JBP1, PRMT5, SKB1, SKB1 homolog, SKB1Hs

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Galerie de données de validation

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  WB analysis using 68534-1-Ig (same clone as 68534-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68534-1-Ig (PRMT5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68534-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68534-1-PBS cible PRMT5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: PRMT5 Protéine recombinante Ag9678
• Nom complet: protein arginine methyltransferase 5
• Masse moléculaire calculée: 637 aa, 73 kDa
• Poids moléculaire observé: 68 kDa
• Numéro d’acquisition GenBank: BC025979
• Symbole du gène: PRMT5
• Identification du gène (NCBI): 10419
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PRMT5 is a Type II enzyme that catalyzes arginine monomethylation and symmetric dimethylation (Rme1 and Rme2s). The many targets of PRMT5 include ribosomal proteins, the histone chaperone nucleoplasmin, p53, and histones. PRMT5 is frequently observed in a complex with the cofactor, methylosome protein 50 (MEP50), which is required for PRMT5 activity. PRMT5 is upregulated in several human malignancies, including lymphomas, lung cancer, breast cancer and colorectal cancer.

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