Anticorps Polyclonal de lapin anti-PRSS8

PRSS8 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15527-1-PBS

Synonymes

CAP1, Channel-activating protease 1, EC:3.4.21.-, Prostasin heavy chain, Prostasin light chain

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Galerie de données de validation

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  WB analysis of mouse kidney using 15527-1-AP (same clone as 15527-1-PBS)

  mouse kidney tissue were subjected to SDS PAGE followed by western blot with 15527-1-AP (PRSS8 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse ovary using 15527-1-AP (same clone as 15527-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse ovary tissue slide using 15527-1-AP (PRSS8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary tumor using 15527-1-AP (same clone as 15527-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 15527-1-AP (PRSS8 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 15527-1-AP (same clone as 15527-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 15527-1-AP (PRSS8 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 15527-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15527-1-PBS cible PRSS8 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PRSS8 Protéine recombinante Ag7234
• Nom complet: protease, serine, 8
• Masse moléculaire calculée: 36 kDa
• Poids moléculaire observé: 39 kDa
• Numéro d’acquisition GenBank: BC001462
• Symbole du gène: PRSS8
• Identification du gène (NCBI): 5652
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Protease serine S1 family member 8 (PRSS8), a membrane-anchored serine protease, has been reported to be involved in the development of several human cancers. PRSS8 protein level was highly expressed in well differentiated cancer cell and was lower or absent in poorly differentiated cancer cell. Significantly higher levels of prostasin were found in early stage OVC serum samples compared to benign ovarian and normal donor samples. Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of OVC. (PMID: 27036110, PMID: 27050145)

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