Anticorps Polyclonal de lapin anti-PRUNE2

• Phare
• Validé par KD/KO

PRUNE2 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11458-1-PBS

Synonymes

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Galerie de données de validation

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  IHC staining of human liver cancer using 11458-1-AP (same clone as 11458-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 11458-1-AP (PRUNE2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11458-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11458-1-PBS cible PRUNE2 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PRUNE2 Protéine recombinante Ag2025
• Nom complet: prune homolog 2 (Drosophila)
• Masse moléculaire calculée: 341 kDa
• Poids moléculaire observé: 140~150 kDa
• Numéro d’acquisition GenBank: BC019095
• Symbole du gène: PRUNE2
• Identification du gène (NCBI): 158471
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PRUNE2 gene, also named BMCC1, encodes protein prune homolog 2. PRUNE2 gene are overlapping with PCA3, one of the most prostate cancer specific markers. PRUNE2 may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. Besides its high level of expression seen in the nervous system (brain, cerebellum and spinal cord), it is also expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. The Calculated molecular weight of this protein is 340 kDa. Our antibody specifically recognises the 140-150 kDa band which is an isoform or cleaved fragment of PRUNE2 (PMID:21234814).

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