Anticorps Recombinant de lapin anti-Presenilin-1-Specific

Presenilin-1-Specific Recombinant Antibody for Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

240615B3

N° de cat : 83618-1-PBS

Synonymes

PSEN1-Specific, PSEN1, Presenilin-1 CTF12, Presenilin-1 CTF subunit, Presenilin-1

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Galerie de données de validation

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  Cytometric bead array standard curve of MP00597-1

  Cytometric bead array standard curve of MP00597-1, Presenilin-1 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 83618-2-PBS. Detection antibody: 83618-1-PBS. Standard: SY00068. Range: 39-5000 pg/mL.

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Informations sur le produit

83618-1-PBS cible Presenilin-1-Specific dans les applications de Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: presenilin 1
• Masse moléculaire calculée: 53 kDa
• Numéro d’acquisition GenBank: NM_000021
• Symbole du gène: PSEN1
• Identification du gène (NCBI): 5663
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.

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