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Anticorps Polyclonal de lapin anti-PTCH2

PTCH2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55091-1-PBS

Synonymes

UNQ560/PRO1121/PRO57079, PTC2, Protein patched homolog 2, patched homolog 2 (Drosophila), Patched 2

Galerie de données de validation

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  • Western Blot (WB) analysis of HepG2 cells using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis of HepG2 using 55091-1-AP (same clone as 55091-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis using 55091-1-AP (same clone as 55091-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human brain tissue using PTCH2 Polyclonal antibody (55091-1-AP)

    WB analysis of human brain using 55091-1-AP (same clone as 55091-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

Informations sur le produit

55091-1-PBS cible PTCH2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet patched homolog 2 (Drosophila)
Masse moléculaire calculée 131 kDa
Poids moléculaire observé 131-140 kDa
Numéro d’acquisition GenBankNM_003738
Symbole du gène PTCH2
Identification du gène (NCBI) 8643
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2.

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