Anticorps Polyclonal de lapin anti-PTPMT1

• Phare
• Validé par KD/KO

PTPMT1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11493-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

  mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

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  WB analysis of rat pancreas using 11493-1-AP (same clone as 11493-1-PBS)

  rat pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11493-1-AP (PTPMT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11493-1-PBS cible PTPMT1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PTPMT1 Protéine recombinante Ag2063
• Nom complet: protein tyrosine phosphatase, mitochondrial 1
• Masse moléculaire calculée: 201 aa, 23 kDa
• Poids moléculaire observé: 21-23 kDa
• Numéro d’acquisition GenBank: BC020242
• Symbole du gène: PTPMT1
• Identification du gène (NCBI): 114971
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Protein Tyrosine Phosphatase localized to the Mitochondrial 1 (PTPMT1) is a highly conserved, dual-specific phosphatase that resides on the matrix-facing side of the inner mitochondrial membrane (IMM). PTPMT1 is a mitochondrial phosphatase and a vital regulator of mitochondrial activities. Current work points to roles for PTPMT1 in the regulation of mitochondrial respiration, dynamics, and ultrastructure through the modulation of pyruvate importation, the tuning of TCA cycle activity, and the synthesis of cardiolipin. PTPMT1 is highly expressed in pancreatic b cells, whose mitochondria have the important function of coupling glucose metabolism to the secretion of insulin. (PMID: 16337125, PMID: 16061174, PMID: 33335799)

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