Anticorps Polyclonal de lapin anti-PTPRK

PTPRK Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28151-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 28151-1-AP (same clone as 28151-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28151-1-AP (PTPRK antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28151-1-PBS in a different storage buffer formulation.

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  WB analysis using 28151-1-AP (same clone as 28151-1-PBS)

  mouse spleen tissue were subjected to SDS PAGE followed by western blot with 28151-1-AP (PTPRK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28151-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28151-1-PBS cible PTPRK dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PTPRK Protéine recombinante Ag27765
• Nom complet: protein tyrosine phosphatase, receptor type, K
• Masse moléculaire calculée: 1439 aa, 162 kDa
• Poids moléculaire observé: 100-120 kDa
• Numéro d’acquisition GenBank: BC140775
• Symbole du gène: PTPRK
• Identification du gène (NCBI): 5796
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PTPRK (Protein Tyrosine Phosphatase Receptor Type Kappa), a member of the receptor-type protein tyrosine phosphatase family, is a transmembrane protein that regulates cell-cell contact. PTPRK is a 210 kDa precursor protein and converted by furin to a mature heterodimeric protein composed of a non-covalently attached amino-terminal extracellular subunit (E-subunit, 120 kDa) and carboxyl-terminal transmembrane subunit (P-subunit, 95 kDa) (PMID: 24882578, 16648485). Loss of PTPRK activity has been observed in pancreatic cancer, primary CNS lymphoma and melanoma, and is associated with poor survival of cancer patients, which suggest that PTPRK is a potential tumor suppressor (PMID: 23696788).

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