Anticorps Polyclonal de lapin anti-PTPRO

PTPRO Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, CoIP, ELISA

Conjugaison

Non conjugué

Publications

12

N° de cat : 12161-1-AP

Synonymes

GLEPP1, PTP U2, PTPase U2, PTPRO, PTPU2, R PTP O

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Galerie de données de validation

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Applications testées

Dilution recommandée

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 3 publications below
• WB: See 12 publications below
• IHC: See 3 publications below
• CoIP: See 1 publications below

Informations sur le produit

12161-1-AP cible PTPRO dans les applications de WB, IHC, CoIP, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: PTPRO Protéine recombinante Ag2802
• Nom complet: protein tyrosine phosphatase, receptor type, O
• Masse moléculaire calculée: 138 kDa
• Numéro d’acquisition GenBank: BC035960
• Symbole du gène: PTPRO
• Identification du gène (NCBI): 5800
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

PTPRO(receptor-type tyrosine-protein phosphatase O) is also named as GLEPP1, PTPU2 and belongs to the protein-tyrosine phosphatase family. The protein is a receptor-like membrane protein tyrosine phosphatase expressed at the apical membrane of the podocyte foot processes in the kidney(PMID:21722858). The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). In reducing conditions, PTPRO can form a smear from 180 to 220 kDa; In non-reducing conditions, a band appeares around 350 kDa, which likely represents the dimeric form of full-length PTPRO (PMID: 19573017).

Publications

Species	Application	Title
human, mouse	WB	Hepatology; Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.; Authors - Hou Jiajie J
mouse	WB,IHC	J Hepatol; PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-κB.; Authors - Hou Jiajie J
mouse	WB	Oncotarget; PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.; Authors - Wenjie Zhang
human,mouse	WB	Cancer Commun (Lond); PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.; Authors - Weixing Dai
mouse	WB	Cell Physiol Biochem; PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor κB Pathway.; Authors - Caihong Liang
human	WB	Front Pharmacol; Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance.; Authors - Hongmei Dong ; KD Validated