Anticorps Recombinant de lapin anti-PTPRS

PTPRS Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

241005B6

N° de cat : 83833-5-PBS

Synonymes

Receptor-type tyrosine-protein phosphatase S, R PTP sigma, R PTP S, PTPSIGMA, EC:3.1.3.48

---

Galerie de données de validation

• 

  WB analysis using 83833-5-RR (same clone as 83833-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83833-5-RR (rPTPσ antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83833-5-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 83833-5-RR

  Biolayer interferometry (BLl) kinetic assays of 83833-5-RR against Human PTPRS were performed. The affinity constant is 68.9 pM.

---

Informations sur le produit

83833-5-PBS cible PTPRS dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: protein tyrosine phosphatase, receptor type, S
• Masse moléculaire calculée: 217 kDa
• Poids moléculaire observé: 140 kDa, 217 kDa
• Numéro d’acquisition GenBank: NM_002850
• Symbole du gène: PTPRS
• Identification du gène (NCBI): 5802
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Protein tyrosine phosphatase receptor type S (PTPRS, also known as R-PTP-S, PTPSIGMA, and R-PTP-sigma) is an integral membrane protein. It can promote oligomerization by binding to large heparan sulfate proteoglycan structures, and interact with NTRK1/3, PPFIA1/2/3 (PMID: 25385546; 8524829; 9624153). The non-glycosylated molecular weight of PTPRS is 214 kDa, and the extracellular domain can be cleaved near the cell membrane by an endoprotease to generate a glycated 140 kDa protein. Variations and mutations of PTPRS are associated with Alzheimer's disease and cholangiocarcinoma (PMID: 38766183; 35991009).

{{ptg:RelatedPrimaryAntibodies}}