Anticorps Recombinant de lapin anti-Phospho-FRS2 (Tyr436)

Phospho-FRS2 (Tyr436) Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242134H8

N° de cat : 85242-1-PBS

Synonymes

P FRS2 (Tyr436), P-FRS2 (Tyr436), Phos FRS2 (Tyr436), Phos-FRS2 (Tyr436), Phospho-FRS2-α (Tyr436)

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Galerie de données de validation

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  WB analysis of NIH/3T3 using 85242-1-RR (same clone as 85242-1-PBS)

  Non-treated NIH/3T3 cells and bFGF (HZ-1285) treated NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 85242-1-RR (Phospho-FRS2 (Tyr436) antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Alpha Tubulin (66031-1-Ig) antibody as loading control. This data was developed using the same antibody clone with 85242-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85242-1-PBS cible Phospho-FRS2 (Tyr436) dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: fibroblast growth factor receptor substrate 2
• Masse moléculaire calculée: 60 kDa
• Poids moléculaire observé: 80-85 kDa
• Numéro d’acquisition GenBank: BC021562
• Symbole du gène: FRS2
• Identification du gène (NCBI): 10818
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Fibroblast growth factor substrate 2 (FRS2), a lipid-anchored docking protein that is phosphorylated upon activation of FGFR, is critical for recruitment of downstream signaling molecules and links the FGFRs to the Ras/Mek/Erk pathway and the PI3-Kinase/Akt pathway. Studies have found that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc, suggesting a model in which competitive binding between FRS-2 and Shc regulates differentiation versusproliferation. (PMID: 19053057, PMID: 10092678)

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