Anticorps Polyclonal de lapin anti-Phospho-INPPL1 (Tyr986/987)

Phospho-INPPL1 (Tyr986/987) Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29574-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29574-1-AP (same clone as 29574-1-PBS)

  Non-treated and UV treated HeLa cells were subjected to SDS PAGE followed by western blot with 29574-1-AP (Phospho-INPPL1 (Tyr986/987) antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with INPPL1 antibody (26678-1-AP) subsequently. This data was developed using the same antibody clone with 29574-1-PBS in a different storage buffer formulation.

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  WB analysis using 29574-1-AP (same clone as 29574-1-PBS)

  Non-treated and UV treated NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 29574-1-AP (Phospho-INPPL1 (Tyr986/987) antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with INPPL1 antibody (26678-1-AP) subsequently. This data was developed using the same antibody clone with 29574-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29574-1-PBS cible Phospho-INPPL1 (Tyr986/987) dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: inositol polyphosphate phosphatase-like 1
• Masse moléculaire calculée: 1258 aa, 139 kDa
• Poids moléculaire observé: 150 kDa
• Numéro d’acquisition GenBank: BC140853
• Symbole du gène: INPPL1
• Identification du gène (NCBI): 3636
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Inositol polyphosphate phosphatase-like protein 1(INPPL1) belongs to the inositol and phosphatidylinositol 5-phosphatase family, also known as SH2 domain-containing inositol 5'-phosphatase 2(SHIP2), is ubiquitous in all organizations. SHIP2 is constitutively tyrosine-phosphorylated in chronic myeloid leukemia progenitor cells. In B cells, SHIP2 was most tyrosine phosphorylated after BCR and FC-γriib crosslinking and was associated with Shc, but not after BCR stimulation alone. It has also been shown that SHIP2 can be phosphorylated at Tyr-986 in COS-7 cells and Chinese hamster ovary cells overexpressing the insulin receptor. (PMID: 11349134)

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