Anticorps Recombinant de lapin anti-Phospho-SMAD1 (Ser187)

Phospho-SMAD1 (Ser187) Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250292C10

N° de cat : 85388-4-PBS

Synonymes

Phospho SMAD1 (Ser187), Phospho SMAD1(Ser187), Phospho-SMAD1, Phospho-SMAD1(Ser187), Phospho-SMAD1-Ser187

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Galerie de données de validation

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  WB analysis of HepG2 using 85388-4-RR (same clone as 85388-4-PBS)

  Non-treated HepG2 cells and BMP2 treated HepG2 cells were subjected to SDS PAGE followed by western blot with 85388-4-RR (Phospho-SMAD1 (Ser187) antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with GAPDH (60004-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 85388-4-PBS in a different storage buffer formulation.

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Informations sur le produit

85388-4-PBS cible Phospho-SMAD1 (Ser187) dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: SMAD family member 1
• Masse moléculaire calculée: 52 kDa
• Numéro d’acquisition GenBank: BC001878
• Symbole du gène: SMAD1
• Identification du gène (NCBI): 4086
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Transforming growth factor-β (TGF-β) superfamily is recognized as one of the largest families of secreted multifunctional peptides exerting different biological effects on a large variety of cell types, such as regulation of hormone secretion, stimulation of extracellular matrix formation, the inhibition of proliferation of many cell types, cell survival, bone formation, and chemotaxis for inflammatory cells. One of the most important proteins that modulate TGF-β ligand activity is the SMAD family proteins. SMAD1 is one of the receptor-activated Smads. It's also a signal transducers of BMP signaling and binds to several proteins involved in ubiquitin-proteasome system (UPS).

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