Anticorps Recombinant de lapin anti-Phospho-TBC1D1 (Ser660)

Phospho-TBC1D1 (Ser660) Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

7N19

N° de cat : 81363-2-PBS

Synonymes

TBC1D1, TBC1 domain family member 1, TBC1, KIAA1108, 7N19

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Galerie de données de validation

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  WB analysis using 81363-2-RR (same clone as 81363-2-PBS)

  Non-treated and Calyculin A treated NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 81363-2-RR (Phospho-TBC1D1 (Ser660) antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Alpha Tubulin antibody as loading control. This data was developed using the same antibody clone with 81363-2-PBS in a different storage buffer formulation.

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  WB analysis using 81363-2-RR (same clone as 81363-2-PBS)

  Non-treated and Calyculin A treated HeLa cells were subjected to SDS PAGE followed by western blot with 81363-2-RR (Phospho-TBC1D1 (Ser660) antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Alpha Tubulin antibody as loading control. This data was developed using the same antibody clone with 81363-2-PBS in a different storage buffer formulation.

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Informations sur le produit

81363-2-PBS cible Phospho-TBC1D1 (Ser660) dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
• Masse moléculaire calculée: 133 kDa
• Poids moléculaire observé: 160 kDa
• Numéro d’acquisition GenBank: BC050321
• Symbole du gène: TBC1D1
• Identification du gène (NCBI): 23216
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TBC1D1 belong to the family of RabGAPs and its physiological roles in glucose homeostasis and its implication in human diseases have already been characterized in skeletal muscle and adipocytes in a large number of independent studies. TBC1D1 including twophospho-tyrosine-binding (PTB) domains, a calmodulin-binding domain(CBD) and the func-tional GAP domain responsible for catalyzing GTP hydrolysis. TBC1D1 is phosphorylated by AMPK at Ser660 and Thr237, and by AKT at Thr596. The RabGAPs TBC1D1 is important regulators of glucose homeostasis inskeletal muscle and adipose tissue. (PMID: 31627187, PMID: 18477703)

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