Anticorps Polyclonal de lapin anti-Phospho-TBC1D1 (Ser707)

Phospho-TBC1D1 (Ser707) Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29068-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29068-1-AP (same clone as 29068-1-PBS)

  Non-treated and Calyculin A treated HEK-293T cells were subjected to SDS PAGE followed by western blot with 29068-1-AP (Phospho-TBC1D1 (Ser707) antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin antibody as the loading control. This data was developed using the same antibody clone with 29068-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29068-1-PBS cible Phospho-TBC1D1 (Ser707) dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
• Masse moléculaire calculée: 133 kDa
• Poids moléculaire observé: 150-160 kDa
• Numéro d’acquisition GenBank: BC050321
• Symbole du gène: TBC1D1
• Identification du gène (NCBI): 23216
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TBC1D1 belong to the family of RabGAPs and its physiological roles in glucose homeostasis and its implication in human diseases have already been characterized in skeletal muscle and adipocytes in a large number of independent studies. TBC1D1 including twophospho-tyrosine-binding (PTB) domains, a calmodulin-binding domain(CBD) and the func-tional GAP domain responsible for catalyzing GTP hydrolysis. TBC1D1 is phosphorylated by AMPK at Ser660 and Thr237, and by AKT at Thr596. The RabGAPs TBC1D1 is important regulators of glucose homeostasis inskeletal muscle and adipose tissue. (PMID: 31627187, PMID: 18477703)

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