Anticorps Recombinant de lapin anti-Podoplanin

Podoplanin Recombinant Antibody for Sandwich ELISA, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Sandwich ELISA, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251406D4

N° de cat : 86750-1-PBS

Synonymes

PDPN, 29kDa cytosolic podoplanin intracellular domain, Aggrus, PA2.26 antigen, PSEC0003

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Galerie de données de validation

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  Sandwich ELISA sample test of MP02738-1

  Plasma of eight individual healthy human donors was measured. The Podoplanin concentration of detected samples was determined to be 85.9 pg/mL with a range of 37.1-122.1 pg/mL.

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  Sandwich ELISA standard curve of MP02738-1

  Sandwich ELISA standard curve of MP02738-1, Human Podoplanin Recombinant Matched Antibody Pair - PBS only. 86750-1-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard Eg5024. 86750-5-PBS was HRP conjugated as the detection antibody. Range: 39.1-2500 pg/mL.

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Informations sur le produit

86750-1-PBS cible Podoplanin dans les applications de Sandwich ELISA, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Podoplanin Protéine recombinante Eg5024
• Nom complet: podoplanin
• Numéro d’acquisition GenBank: BC014668
• Symbole du gène: Podoplanin
• Identification du gène (NCBI): 10630
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Podoplanin was identified as a 43 kDa glycoprotein found in the cell membranes of glomerular epithelial cells (podocyte) (PMID: 9327748). It is a lymphatic marker because the expression of podoplanin has been detected in lymphatic but not blood vascular endothelium, and is useful as a marker of tumor-associated Lymphangiogenesis. Podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells. It may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, PDPN induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility, and decreased cell adhesion. It is required for normal lung cell proliferation and alveolus formation at birth. PDPN induces platelet aggregation. It does not have any effect on folic acid or amino acid transport and does not function as a water channel or as a regulator of aquaporin-type water channels.

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