Anticorps Recombinant de lapin anti-Presenilin-1-Specific

Presenilin-1-Specific Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, singe, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250834G3

N° de cat : 83618-5-PBS

Synonymes

Presenilin-1, PSEN1, AD3, presenilin 1, Presenilin1

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Galerie de données de validation

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  WB analysis using 83618-5-RR (same clone as 83618-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83618-5-RR (PSEN1-S310 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83618-5-PBS in a different storage buffer formulation.

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Informations sur le produit

83618-5-PBS cible Presenilin-1-Specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, singe, souris

• Réactivité: Humain, rat, singe, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: presenilin 1
• Masse moléculaire calculée: 467 aa, 53 kDa
• Poids moléculaire observé: 21 kDa, 53 kDa
• Numéro d’acquisition GenBank: BC011729
• Symbole du gène: PSEN1
• Identification du gène (NCBI): 5663
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.

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