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Anticorps Monoclonal anti-Protein Z

Protein Z Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2A1D3

N° de cat : 68394-1-PBS

Synonymes

PROZ, PZ, Vitamin K dependent protein Z

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using Protein Z Monoclonal antibody (68394-1-Ig)

    WB analysis using 68394-1-Ig (same clone as 68394-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68394-1-Ig (Protein Z antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68394-1-PBS in a different storage buffer formulation.

Informations sur le produit

68394-1-PBS cible Protein Z dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG2a
Clonalité Monoclonal
Type Anticorps
Immunogène Protein Z Protéine recombinante Ag13051
Nom complet protein Z, vitamin K-dependent plasma glycoprotein
Masse moléculaire calculée 400 aa, 45 kDa
Poids moléculaire observé 45-47 kDa, 27 kDa
Numéro d’acquisition GenBankBC074906
Symbole du gène PROZ
Identification du gène (NCBI) 8858
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Protein Z (PZ, PROZ) is a vitamin K-dependent plasma protein that serves as a cofactor for activated factor X inhibition by the PZ-dependent protease inhibitor (PMID: 16938126). Reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding (PMID: 7495103) and deep vein thrombosis (DVT) (PMID: 10829076), as well as in unexplained abortions with early fetal loss (PMID: 11895801), late fetal demise and intrauterine growth restriction (PMID: 16260213), acute coronary syndromes (PMID: 14652653), and stroke (PMID: 11570404). In addition, PZ may be a biomarker for the early diagnosis of pancreatic cancer (PMID: 31025496). It has two isoforms with molecular weights of 44 kDa and 47 kDa.

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