Anticorps Polyclonal de lapin anti-QPCT

QPCT Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18571-1-PBS

Synonymes

EC, EC:2.3.2.5, Glutaminyl cyclase, glutaminyl peptide cyclotransferase, Glutaminyl-peptide cyclotransferase

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Galerie de données de validation

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  WB analysis using 18571-1-AP (same clone as 18571-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18571-1-AP (QPCT antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18571-1-PBS in a different storage buffer formulation.

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  WB analysis using 18571-1-AP (same clone as 18571-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18571-1-AP (QPCT antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18571-1-PBS in a different storage buffer formulation.

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  IF Staining of HEK-293 using 18571-1-AP (same clone as 18571-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using QPCT antibody (18571-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 18571-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18571-1-PBS cible QPCT dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: QPCT Protéine recombinante Ag13416
• Nom complet: glutaminyl-peptide cyclotransferase
• Masse moléculaire calculée: 361 aa, 41 kDa
• Poids moléculaire observé: 41 kDa, 35 kDa
• Numéro d’acquisition GenBank: BC047756
• Symbole du gène: QPCT
• Identification du gène (NCBI): 25797
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Glutaminyl-peptide cyclotransferase (QPCT) gene encodes glutaminyl cyclase (QC), an enzyme that plays a role in post-translational modification of proteins by converting N-terminal glutamate to pyroglutamine. QPCT plays a specific role in promoting tumor cell proliferation, migration and angiogenesis as well as in inhibiting tumor cell apoptosis in cancers such as thyroid cancer and renal cell carcinoma (PMID: 38417050). Human QPCT has two isoforms produced by alternative splicing, 41 kDa and 35 kDa, respectively.

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