Anticorps Polyclonal de lapin anti-QSER1

QSER1 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55326-1-PBS

Synonymes

glutamine and serine rich 1

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Galerie de données de validation

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  IHC staining of human pancreas cancer using 55326-1-AP (same clone as 55326-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 55326-1-AP (QSER1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 55326-1-AP (same clone as 55326-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 55326-1-AP (QSER1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

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  IF Staining of HeLa using 55326-1-AP (same clone as 55326-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HeLa cells using QSER1 antibody (55326-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

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Informations sur le produit

55326-1-PBS cible QSER1 dans les applications de IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: glutamine and serine rich 1
• Masse moléculaire calculée: 190 kDa
• Numéro d’acquisition GenBank: NM_001076786
• Symbole du gène: QSER1
• Identification du gène (NCBI): 79832
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

QSER1, a recently characterized protein, whose activity has been tightly associated with the protection of DNA methylation sites in hESCs. QSER1 is widely up-regulated in multiple cancers, and its up-regulation correlates with poor clinic outcomes (PMID: 36371602). QSER1 depletion leads to NODAL de-repression and associates with increased RNA Polymerase II occupancy at YAP1bound enhancers, pointing to a QSER1 contribution maintaining low transcriptional activity on certain genomic regions (PMID: 33833093, 35210841).

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