Anticorps Polyclonal de lapin anti-RAMP2

RAMP2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13223-2-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse brain using 13223-2-AP (same clone as 13223-2-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 13223-2-AP (RAMP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 13223-2-AP (same clone as 13223-2-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 13223-2-AP (RAMP2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

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Informations sur le produit

13223-2-PBS cible RAMP2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RAMP2 Protéine recombinante Ag4028
• Nom complet: receptor (G protein-coupled) activity modifying protein 2
• Masse moléculaire calculée: 175 aa, 20 kDa
• Poids moléculaire observé: 20 kDa
• Numéro d’acquisition GenBank: BC027975
• Symbole du gène: RAMP2
• Identification du gène (NCBI): 10266
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RAMP2 (receptor-activity-modifying protein) is a member of the RAMP family of single-transmembrane-domain proteins which consist of an N-terminal extracellular domain, a transmembrane region and a short intracellular C-terminal tail. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a G protein-coupled receptor, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. RAMP1 transports the CRLR to the plasma membrane and then remains associated with it to function as a terminally glycosylated CGRP receptor, while RAMP2 and RAMP3 transfer the CRLR to the cell surface to generate receptors that are preferentially selective for adrenomedullin. (PMID: 9620797; 16188935)

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