Anticorps Polyclonal de lapin anti-RBBP8

• Phare
• Validé par KD/KO

RBBP8 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12624-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of Raji using 12624-1-AP (same clone as 12624-1-PBS)

  Raji cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

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  WB analysis of A431 using 12624-1-AP (same clone as 12624-1-PBS)

  A431 cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

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Informations sur le produit

12624-1-PBS cible RBBP8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RBBP8 Protéine recombinante Ag3314
• Nom complet: retinoblastoma binding protein 8
• Masse moléculaire calculée: 103 kDa
• Poids moléculaire observé: 120 kDa
• Numéro d’acquisition GenBank: BC030590
• Symbole du gène: RBBP8
• Identification du gène (NCBI): 5932
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations

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