Anticorps Recombinant de lapin anti-RBPJ

RBPJ Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243044G4

N° de cat : 85676-3-PBS

Synonymes

CBF 1, CBF1, CBF-1, csl, IGKJRB

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Galerie de données de validation

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  WB analysis using 85676-3-RR (same clone as 85676-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85676-3-RR (RBPJ antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85676-3-PBS in a different storage buffer formulation.

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Informations sur le produit

85676-3-PBS cible RBPJ dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: RBPJ Protéine recombinante Ag32552
• Nom complet: recombination signal binding protein for immunoglobulin kappa J region
• Masse moléculaire calculée: 56 kDa
• Poids moléculaire observé: ~60 kDa
• Numéro d’acquisition GenBank: BC064976
• Symbole du gène: RBPJ
• Identification du gène (NCBI): 3516
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RBPJ, also named as IGKJRB, IGKJRB1, RBPJK, RBPSUH, NY-REN-30, CBF-1 and CSL, belongs to the Su(H) family. It is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. RBPJ acts as a transcriptional repressor when it is not associated with Notch proteins. It is specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. RBPJ binds to the Runx3 promoter in the atrioventricular canal in vivo, and inhibition of Notch reduces RUNX3 expression in the cardiac cushion of embryonic hearts.

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