Anticorps Polyclonal de lapin anti-RETSAT

RETSAT Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16895-1-PBS

Synonymes

All-trans-13,14-dihydroretinol saturase, All-trans-retinol 13,14-reductase, EC:1.3.99.23, PPAR-alpha-regulated and starvation-induced gene protein, PPSIG

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Galerie de données de validation

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  WB analysis using 16895-1-AP (same clone as 16895-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16895-1-AP (RETSAT antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16895-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16895-1-PBS cible RETSAT dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RETSAT Protéine recombinante Ag10420
• Nom complet: retinol saturase (all-trans-retinol 13,14-reductase)
• Masse moléculaire calculée: 610 aa, 69 kDa
• Poids moléculaire observé: 62-67 kDa
• Numéro d’acquisition GenBank: BC011418
• Symbole du gène: RETSAT
• Identification du gène (NCBI): 54884
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RETSAT (Retinol Saturase) is an enzyme-encoding gene that plays a critical role in cellular metabolism, primarily involved in the saturation of retinol (vitamin A) and other molecules. It catalyzes the conversion of all-trans-retinol to all-trans-13,14-dihydroretinol, a process that links vitamin A metabolism to lipid and glucose homeostasis. It is highly expressed in the liver, adipose tissue, and kidney and is regulated by the PPARγ master regulator of adipogenesis (PMID: 28855500; 38128827). RETSAT also has a role in cancer cell survival, particularly in hypoxic tumor environments, by enhancing resistance to replication stress (PMID: 36109793).

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