Anticorps Polyclonal de lapin anti-RGS13

RGS13 Polyclonal Antibody for IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12396-1-PBS

Synonymes

Regulator of G-protein signaling 13

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Galerie de données de validation

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  IP experiment of Ramos using 12396-1-AP (same clone as 12396-1-PBS)

  IP result of anti-RGS13 (IP:12396-1-AP, 4ug; Detection:12396-1-AP 1:500) with Ramos cells lysate 1680 ug. This data was developed using the same antibody clone with 12396-1-PBS in a different storage buffer formulation.

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  IHC staining of human lymphoma using 12396-1-AP (same clone as 12396-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 12396-1-AP (RGS13 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 12396-1-PBS in a different storage buffer formulation.

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Informations sur le produit

12396-1-PBS cible RGS13 dans les applications de IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RGS13 Protéine recombinante Ag3077
• Nom complet: regulator of G-protein signaling 13
• Masse moléculaire calculée: 159 aa, 19 kDa
• Poids moléculaire observé: 17-19 kDa
• Numéro d’acquisition GenBank: BC016667
• Symbole du gène: RGS13
• Identification du gène (NCBI): 6003
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Regulator of G-protein signaling 13 (RGS13) is an R4 subfamily member that attenuates both Gαi and Gαq-dependent signaling including chemokine reponses in B cells (PMID: 11875076, PMID: 12193720). RGS13 interacted with both Gialpha and Gqalpha and strongly impaired signaling through G(i)-linked signaling pathways, including signaling through the chemokine receptors CXCR4 and CXCR5 (PMID: 12193720). Human mast cells express multiple RGS proteins, of which RGS13 is among the most abundant (PMID: 19017978).

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