Anticorps Monoclonal anti-RGS3

RGS3 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

1D6A3

N° de cat : 66790-1-PBS

Synonymes

C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ RGS3, RGP3, RGS3

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Galerie de données de validation

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  WB analysis of Jurkat using 66790-1-Ig (same clone as 66790-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 66790-1-Ig (RGS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66790-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 66790-1-Ig (same clone as 66790-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 66790-1-Ig (RGS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66790-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66790-1-PBS cible RGS3 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: RGS3 Protéine recombinante Ag3177
• Nom complet: regulator of G-protein signaling 3
• Masse moléculaire calculée: 1198 aa, 132 kDa
• Poids moléculaire observé: 140 kDa
• Numéro d’acquisition GenBank: BC018072
• Symbole du gène: RGS3
• Identification du gène (NCBI): 5998
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RGS3 belongs to a family of proteins which share the core regulator of G-protein signalling (RGS) domain and function as GTPase-activating proteins (GAPs) for the α subunit of heterotrimeric G-proteins. RGS3 has been reported to inhibit the Gai-and Gaq-mediated signaling pathways in the cardiovascular system, including those acting via the cardiovascular signaling molecules angiotensin II (Ang II), sphingosine 1-phosphate and endothelin-1. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.

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